Principal Investigator: Dr Lloyd Balbuena
University of Saskatchewan, Psychiatry, 103 Hospital Drive, Ellis Hall, Rm 104, Saskatoon S7N 0W8, CanadaTags: 18046, neuroticism, Non-natural deaths, smoking, Suicide
1a: The first research question is if personality (especially neuroticism) is a risk factor for suicide or attempted suicide. The second question is to examine whether characteristics related to family history, personality, mental health, substance use, and hospitalization predict suicidality. Our theoretical framework is that traits, on-going habits, and recent events all contribute to suicidality, but the unavailability of large, longitudinal data has not helped to clarify the relative importance of each factor. We will also examine the association of smoking with suicide or attempted suicide. The literature is growing on this topic but the results reported are inconsistent.
1b: Biobank is intended to be a resource for health researchers investigating disease mechanisms and potential treatments to make future lives better. Our proposed research is a component of larger projects on suicide in Saskatoon, Canada and Swansea, Wales. We hope to make some impact on suicide prevention by studying its antecedent events. This Biobank component, with its rich data, large sample, and longitudinal design, would be an extremely valuable contribution to the evidence on risks for suicide and attempted suicide.
1c: We will examine our research questions by using the entire cohort to calculate the hazard of attempted or completed suicide given the explanatory variables above. Separate survival analysis models for attempted and completed suicide will be created, stratifying by gender and controlling for age, measured as a continuous variable. We will calculate the hazard ratios for each predictor variable controlling for age. Then we will create the best multivariate model using the ROC curve as a criterion.
1d: We will use the entire cohort, since the majority of our exposure variables were measured at baseline.
I would be very much interested in requesting genetic data as part of project 18046.
A natural question we have in mind is whether smoking and neuroticism have shared genetic foundations
We would like to look at the relation of dietary and physical activity variables (as assessed in the food frequency questionnaire). The outcome of interest remains suicide death, and we will also be making use of variables already requested.
There are two variables -“lifetime number of sexual partners” and “age first had sexual intercourse.” These are related to risk-taking and impulsivity which I wish to examine as predictors of suicide.