Principal Investigator: Professor Nicholas Cross
Institution: University of SouthamptonTags: 35273, cancer, jak2 myeloid myeloproliferative uniparental-disomy
We aim to (i) identify common genetic variation that predisposes to chronic myeloproliferative neoplasms (a type of blood cancer) and (ii) understand the relationship between age-related clonal haematopoiesis and the development of a myeloproliferative phenotype. This study will improve our understanding of genetic factors that contribute to the onset and severity of myeloproliferative neoplasms. We anticipate that our findings will improve methods to diagnose and stage these disorders, thus providing a framework for more personalised management. We will perform a genome wide association study by comparing genetic variation in patients with chronic myeloproliferative neoplasms (cases) and the Biobank population (controls). In addition we will analyse the Biobank population for evidence of somatically acquired clonal abnormalities, and relate this information to constitutional genetic factors as well as any available information on blood counts.
We aim to (i) identify common genetic variation that predisposes to chronic myeloproliferative neoplasms (a type of blood cancer) and (ii) understand the relationship between age-related clonal haematopoiesis and the development and the development of a myeloproliferative phenotype
We hope to expand the scope of our project as follows (i) determine if elevated blood counts are related to infectious disease and adjust analysis accordingly (ii) investigate the effect of different medications on clonal haematopoiesis including chemotherapy, retinol and ascorbate which may affect clonality (iii) determine if treatment for medical conditions including lowering blood pressure and/or cholesterol is associated with acquired uniparental disomy (aUPD) and (iv) to use operation data to adjust our analysis for the curative effect of bone marrow transplantation
Last updated Jul 22, 2019